REACTION OF 2-THIOHYDANTOINS WITH SOME DIAZOALKANES AND SOME AMINES

Autor:	Ashraf A. El-Shehawy, Ahmed A. El-Barbary, Youssef L. Aly, Abdel-Fatah M. Hashem
Rok vydání:	2000
Předmět:	Inorganic Chemistry Alanine chemistry.chemical_compound Piperazine chemistry Diazomethane Morpholine Organic Chemistry Anthranilic acid Organic chemistry Piperidine Spectral data Biochemistry
Zdroj:	Phosphorus, Sulfur, and Silicon and the Related Elements. 160:77-91
ISSN:	1563-5325 1042-6507
DOI:	10.1080/10426500008043673
Popis:	Reaction of 2-thiohydantoin derivatives with diazoalkanes as diazomethane. Diphenyldiazomethane and/or 9-diazofluorene was investigated. Several 2-thio- and 2-methylthiohydantoins (IIa,b), (IIIa,b), (XI) and (XII) were prepared via the reaction of 2-thiohydantoins (Ia,b) and (X) with diazomethane. 2-Morpholino- and/or 2-piperidino- glycocyamidines (VIIa,b) and (XVa,b) were prepared by reacting 2-alkylthiohydantoins (IIla) and (XII), respectively, with morpholine and/or piperidine. Moreover, treating of two equivalents of XIVa-d with one equivalent of piperazine afforded 1,4[di-(5-phenylmethylene-hydantoinyl)]-piperazines (XVIa,b). The behaviour of 2-alkylthiohydantoins towards alanine and anthranilic acid was also investigated. The structure of the products was established by correct analytical and spectral data as well as by chemical evidencies.
Databáze:	OpenAIRE
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