ChemInform Abstract: Efficient Post-Macrocyclization Functionalizations of Oxacalix[2]arene[2]pyrimidines

Autor:	Margriet Ovaere, Lingam Kishore, Wim Van Rossom, Wouter Maes, Luc Van Meervelt, Wim Dehaen
Rok vydání:	2008
Předmět:	Substitution reaction chemistry.chemical_compound Pyrimidine chemistry Nucleophilic aromatic substitution Aryl Calixarene General Medicine Combinatorial chemistry
Zdroj:	ChemInform. 39
ISSN:	1522-2667 0931-7597
DOI:	10.1002/chin.200830168
Popis:	Diversely functionalized oxacalix[2]arene[2]pyrimidines have been synthesized starting from a bis(methylsulfanyl)-substituted oxacalix[4]arene by two efficient post-macrocyclization pathways. Functionalized aryl groups were introduced on the pyrimidine building block via Liebeskind−Srogl cross-coupling reactions, while a variety of O-, S-, N-, and C-nucleophiles were inserted on the calixarene skeleton by nucleophilic aromatic substitution reactions on the bis(methylsulfonyl)oxacalix[4]arene analogue.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::7dd4e2dee1c45424f331a773b7212f1d https://doi.org/10.1002/chin.200830168 Zobrazit plný text záznamu Plný text