Correlation between the percentage of memory T cells and IFN-γ level in patients with systemic lupus erythematous

Autor:	Fahrina Ulfah, Kusworini Handono, Hanani Octaviani, Handono Kalim
Rok vydání:	2019
Předmět:	History medicine.diagnostic_test business.industry Helper T lymphocyte Cell Autoantibody Acquired immune system Computer Science Applications Education Flow cytometry Correlation medicine.anatomical_structure Immunology Medicine Cytotoxic T cell business CD8
Zdroj:	Journal of Physics: Conference Series. 1246:012015
ISSN:	1742-6596 1742-6588
Popis:	Systemic Lupus Erythematosus (SLE) is a chronic systemic autoimmune disease with diverse clinical and autoantibodies expression. Immune senescence is mostly affect the adaptive immune system, characterized by decrease of naïve T cells and increase of memory T cells. The aim of this study was to analyze the association between percentage of memory helper T lymphocytes (CD4CD45RO+Th), memory cytotoxic T lymphocyte (CD8CD45RO+Tc) and IFN-γ serum levels in patients with SLE. Subjects were 61 female SLE patients, 16 -56 years old, from Rheumatology Clinic Dr. Saiful Anwar Hospital Malang (SLICC classification criteria, 2012). Severity of disease activity were assessed using MEXSLEDAI score, percentage of memory Th cells, memory Tc cells were examined using flow cytometry and IFN-γ serum level were measured by ELISA. The percentages of memory (CD4+CD45RO+) Th cells, memory (CD8+CD45RO+) Tc cells and IFN-γ levels were significantly higher in SLE patients with SLEDAI score > 5 compared with those having SLEDAI score
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::7dd0cbb7b749f94628d390d15459bd67 https://doi.org/10.1088/1742-6596/1246/1/012015 Zobrazit plný text záznamu