ChemInform Abstract: Regioselective Synthesis of Inhibitors of Histone Acetyl Transferase Covalently Linking Spermidine to the S-Terminus of Coenzyme A and Fragments

Autor:	Georges Roblot, Renée Wylde, Agnès O. Martin, Joseph Parello
Rok vydání:	2010
Předmět:	chemistry.chemical_classification biology Stereochemistry Coenzyme A Regioselectivity General Medicine Histone acetyltransferase Adduct Spermidine chemistry.chemical_compound Enzyme Histone chemistry biology.protein Transferase
Zdroj:	ChemInform. 24
ISSN:	0931-7597
DOI:	10.1002/chin.199346252
Popis:	The reaction of a bromoacetylthioester BrCH2CO-S-R (R radical in the coenzyme A series) with spermidine (Spd) derivatives is investigated and it is established that the adduct SpdCOCH2-S-R 1 is the product of the reaction. Parallel studies with model compounds show that this is a general reaction of bromoacetylthioesters. The synthesis of analogs of 1 is described and they correspond to inhibitors of the histone acetyltransferase.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::7dcbd87a3f5bd6c83c6a0bd955edbfbc https://doi.org/10.1002/chin.199346252 Zobrazit plný text záznamu Plný text