Advances in glioma-associated oncogene (GLI) inhibitors for cancer therapy

Autor:	Yi-Ping Ye, Meng Zhang, Xiaoyu Li, Li-Juan Gao
Rok vydání:	2021
Předmět:	Pharmacology animal structures integumentary system Oncogene Cancer Drug resistance Biology medicine.disease Hedgehog signaling pathway Oncology Cancer stem cell Glioma embryonic structures Cancer research medicine Pharmacology (medical) Signal transduction Hedgehog
Zdroj:	Investigational New Drugs. 40:370-388
ISSN:	1573-0646 0167-6997
DOI:	10.1007/s10637-021-01187-2
Popis:	The Hedgehog/Glioma-associated oncogene homolog (HH/GLI) signaling pathway regulates self-renewal of rare and highly malignant cancer stem cells, which have been shown to account for the initiation and maintenance of tumor growth as well as for drug resistance, metastatic spread and relapse. As an important component of the Hh signaling pathway, glioma-associated oncogene (GLI) acts as a key signal transmission hub for various signaling pathways in many tumors. Here, we review direct and indirect inhibitors of GLI; summarize the abundant active structurally diverse natural GLI inhibitors; and discuss how to better develop and utilize GLI inhibitors to solve the problem of drug resistance in tumors of interest. In summary, GLI inhibitors will be promising candidates for various cancer treatments.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::7dc1e14a45adfd7dbd1e46b4e508bb9d https://doi.org/10.1007/s10637-021-01187-2 Zobrazit plný text záznamu Full text from SpringerLink