Effect of Quercetin Supplement on Some Bone Mineralization Biomarkers in Diabetic Type 2 Patients
| Autor: | Jubran K. Hassan, Adheed Khalid Sharrad, Falah Hassan Sheri |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
medicine.medical_specialty
Antioxidant biology business.industry medicine.medical_treatment Osteoporosis chemistry.chemical_element General Medicine Calcium medicine.disease chemistry.chemical_compound Endocrinology chemistry Diabetes mellitus Internal medicine Osteocalcin biology.protein Vitamin D and neurology Medicine Animal studies business Quercetin |
| Zdroj: | Advances in Pharmacology and Pharmacy. 6:43-49 |
| ISSN: | 2332-0044 2332-0036 |
| DOI: | 10.13189/app.2018.060202 |
| Popis: | Background: Diabetes associated with multiple metabolic problems in the body, including bone mineralization remodeling, osteoporosis and increase risk of fracture. Quercetin is natural flavonoids and according to animal studies; it has potent antioxidant, antidiabetic and protective effect against bone loss due to various causes. Objectives: explore effect of quercetin as nutritional supplement administrated orally on some bone mineralization bio-markers such as calcium, vitamin D and osteocalcin in Iraqi diabetic patients. Methods: interventional double-blind placebo randomized controlled study in which 40 patients with type 2 diabetes mellitus (age range 40-45) assigned randomly (using simple randomization) in either control (n=20) or study (n=20) group. Study group received Quercetin oral supplement as 500mg capsule once daily for three months. Venous blood was used for measuring Serum calcium, 25(OH) vitamin D and osteocalcin at base line and after 3 months. Results: After 3 months treatment with Quercetin; levels of Osteocalcin (28.1±7.6), serum calcium (9.2±1.8) and 25(OH) vitamin D (26.6±8.7) were significantly (p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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