Predictors of Poor Functional Status in Adult Fontan Patients Living at Moderate Altitude
| Autor: | C G Stevens, Kristen Campbell, Kaci Pickett, Joseph Kay, E Yeung, Amber Khanna, Shelley D. Miyamoto, Roni M. Jacobsen |
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| Rok vydání: | 2021 |
| Předmět: |
education.field_of_study
medicine.medical_specialty business.industry medicine.medical_treatment Population VO2 max Hemodynamics Retrospective cohort study 030204 cardiovascular system & hematology Cardiac surgery 03 medical and health sciences 0302 clinical medicine 030228 respiratory system Internal medicine Pediatrics Perinatology and Child Health Cohort medicine Cardiology Cardiology and Cardiovascular Medicine education business human activities Respiratory minute volume Cardiac catheterization |
| Zdroj: | Pediatric Cardiology. 42:1757-1765 |
| ISSN: | 1432-1971 0172-0643 |
| Popis: | Patients who have undergone Fontan palliation have reduced exercise tolerance measured by maximal oxygen consumption (VO2 max). Declining exercise capacity is associated with increased morbidity and mortality. The impact of hemodynamics and other variables on this population’s functional status is not well understood. This study sought to identify variables that predict low VO2 max in Fontan patients living at moderate altitude (5,000–8,000 feet). We performed a retrospective cohort study of 44 adult Fontan patients living at moderate altitude who had undergone cardiopulmonary exercise testing (CPET) and cardiac catheterization. We evaluated hemodynamic parameters measured during catheterization, imaging results, and laboratory studies for correlation with VO2 max measured during CPET. Our study cohort (median age 30 years, 52% female) had exercise impairment with mean VO2 max of 21.6 mL/kg/min. Higher trans-pulmonary gradient (TPG) (p |
| Databáze: | OpenAIRE |
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