Book Reviews
| Autor: | Gale Shu, Emir Hodzic, Sarah Pachner, Stephen W. Barthold, Donna Dail, Diego Cadavid, Andrew R. Pachner |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
Pathology
medicine.medical_specialty Inflammation Biology bacterial infections and mycoses medicine.disease biology.organism_classification Central nervous system disease Chronic infection Lyme disease Neurology Lyme Neuroborreliosis Immunity Immunology medicine biology.protein Neurology (clinical) medicine.symptom Borrelia burgdorferi Antibody |
| Zdroj: | Annals of Neurology. 50:130-131 |
| ISSN: | 1531-8249 0364-5134 |
| DOI: | 10.1002/ana.1093 |
| Popis: | The relationship between chronic infection, antispirochetal immunity, and inflammation is unknown in Lyme neuroborreliosis. In the nonhuman primate model of Lyme neuroborreliosis, we measured spirochetal density in the nervous system and other tissues by polymerase chain reaction and correlated these values to anti-Borrelia burgdorferi antibody in the serum and cerebrospinal fluid, and to inflammation in tissues. Despite substantial presence of Borrelia burgdorferi, the causative agent of Lyme borreliosis, in the central nervous system, only minor inflammation was present there, though skeletal and cardiac muscle, which contained similar levels of spirochete, were highly inflamed. Anti-Borrelia burgdorferi antibody was present in the cerebrospinal fluid but was not selectively concentrated. All infected animals developed anti-Borrelia burgdorferi antibody in the serum, but increased amplitude of antibody was not predictive of higher levels of infection. These data demonstrate that Lyme neuroborreliosis is a persistent infection, that spirochetal presence is a necessary but not sufficient condition for inflammation, and that antibody measured in serum may not predict the severity of infection. |
| Databáze: | OpenAIRE |
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