Synthesis and Biological Evaluation of New Pyrimidine Derivatives

Autor:	O. A. Fathalla, Mosaad S. Mohamed, Samir M. Awad, H. H. Radwan
Rok vydání:	2006
Předmět:	chemistry.chemical_compound Hydrolysis chemistry Pyrimidine Aryl Organic chemistry Uracil Hydrochloric acid General Medicine Antibacterial activity Antimicrobial Methyl iodide
Zdroj:	ChemInform. 37
ISSN:	1522-2667 0931-7597
DOI:	10.1002/chin.200633166
Popis:	4-Oxo-2-thioxo-1,2,3,4-tetrahydropyrimidine (2-thiouracil) 1 is reacted with a series of diazotized aromatic amines to give compounds 2a-f. On the other hand compound 1 is s-methylated by methyl iodide giving 4-oxo-2-methylthioxo 1,2,3,4-tetrahydropyrimidine 3, which intum is reacted with a series of diazotized aromatic amines giving arylazo derivatives of the type 4a-e. In another reaction compound 1 is hydrolysed by monochloroacetic acid in hydrochloric acid into 2,4-dioxo,1,2,3,4-tetrahydropyrimidine (uracil) 5 which is reacted with a series of diazotized aromatic amines giving aryl azo compounds of the type 6a-f. The products showed some cytotoxic activity in addition to antibacterial activity (compounds 2a, 4c, 4d and 6d) and antimicrobial activity (compounds 2a, 4a-e and 6a-f).
Databáze:	OpenAIRE
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