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Background: Diabetic nephropathy (DN) is the major microvascular complication and leading cause of chronic kidney disease (CKD) globally. Early detection of diabetic nephropathy is necessary. Objective: To evaluate the serum beta-2 (β2) microglobulin as a biomarker to predict diabetic nephropathy. Methods: This study was conducted from March 2020 to February 2021 at Department of Laboratory Medicine, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh. A total of 60 patients with type-2 diabetes mellitus (DM) were enrolled purposively. Among them, 30 patients had diabetic nephropathy (group I) and 30 were without diabetic nephropathy (group II). Their random blood sugar (RBS), serum creatinine, estimated glomerular filtration rate (e-GFR), serum beta- 2 (β2) microglobulin and urinary microalbumin levels were measured. Data were analyzed and compared by statistical tests. Results: Most of the patients in nephropathy group were male who belonged to 51 - 60 years age group and their mean e-GFR was significantly decreased (p |
