Оценка состояния интестинальной микрофлоры и содержания короткоцепочечных жирных кислот копрофильтрата у детей с неалкогольной жировой болезнью печени
| Autor: | N.Yu. Zavhorodnia, I.A. Klenina, O.Yu. Lukianenko, N.S. Vishnarevska, O.M. Tatarchuk, O.I. Hrabovska |
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| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Intestinal permeability biology business.industry Fatty liver Gut flora medicine.disease biology.organism_classification Gastroenterology Intestinal absorption 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Internal medicine Lactobacillus Nonalcoholic fatty liver disease medicine 030211 gastroenterology & hepatology Steatosis Transient elastography business |
| Zdroj: | GASTROENTEROLOGY. 54:56-62 |
| ISSN: | 2518-7880 2308-2097 |
| Popis: | Background. Changes in the intestinal microbiome trigger the development and progression of non-alcoholic fatty liver disease (NAFLD). Adverse fluctuations in intestinal microbiota are associated with increased intestinal permeability, activation of mucosal and adaptive immunity, increase in production and intestinal absorption of short-chain fatty acids (SCFA). The ratio of acetic, propionic, butyric acid is an important indicator of the integrity of the microbial community of the intestine. Thus, the study of the gut microbiota composition and short-chain fatty acids production represents a very appealing approach to increasing our knowledge about the mechanisms leading to NAFLD in children. The purpose of the study was to determine the features of the fecal short-chain fatty acids (fSCFA) content and the colonic microbiota composition in children with NAFLD. Materials and methods. A comprehensive examination of 102 children was provided in the Department of Pediatric Gastroenterology of the Institute of Gastroenterology of the National Academy of Medical Sciences of Ukraine. According to the presence of obesity, transient elastography data and alanine aminotransferase levels the patients were divided into four groups: I group — children with simple hepatic steatosis (n = 24); II group — children with nonalcoholic steatohepatitis (NASH) (n = 14); III group — children with obesity without steatosis (n = 48), IV group — children with normal weight (n = 16). Chromatographic study of fSCFA was conducted using gas chromatograph Chromatec-Crystal 5000. The microorganisms were identified using a microbiological study of the colon content. Diagnosis of NAFLD was established with FibroScan 502 Touch (Echosens, France) with the determination of the controlled attenuation parameter. Results. Significant changes in the spectrum of fSCFA were observed in children of the III group with acetic acid content increased by 4.8 times (р |
| Databáze: | OpenAIRE |
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