Shortcut to Selectivity: Make Them All and Let Preparative Chromatography Sort it Out

Autor:	Derek W. Henderson, Christopher J. Welch, Dave Conlon, Mohamed Shaimi, Brenda Pipik, David J. Schenk
Rok vydání:	2010
Předmět:	Solvent chemistry.chemical_compound Chromatography chemistry Organic Chemistry Diol Organic chemistry Physical and Theoretical Chemistry Selectivity Derivative (chemistry) Single isomer
Zdroj:	Organic Process Research & Development. 14:905-907
ISSN:	1520-586X 1083-6160
DOI:	10.1021/op100095e
Popis:	Preparative chromatography was used to overcome the difficult selectivity challenge of accessing a single isomer of a mono tert-butyldimethylsilyl (TBDMS) derivative of an unsymmetrical diol. Chromatographic purification allowed rapid purification of more than 10 kg of the desired intermediate from the statistical mixture of undesired mono-TBDMS, bis-TBDMS, and very strongly retained, unreacted starting material. A noteworthy injection cycle strategy of performing three injections, then desorbing the accumulated strongly bound diol starting material with a strong solvent wash was employed in the separation.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::7da546140bf62b7883f1709340104661 https://doi.org/10.1021/op100095e Zobrazit plný text záznamu