Early atherosclerosis in ulcerative colitis: cross-sectional case-control study

Autor:	Pravir A Gambhire, Pravin Rathi, Samit S Jain, Dharmesh K Shah, Qais Contractor, Ravi U. Varma
Rok vydání:	2015
Předmět:	medicine.medical_specialty medicine.diagnostic_test Homocysteine Cross-sectional study business.industry Gastroenterology Case-control study medicine.disease Ulcerative colitis chemistry.chemical_compound Endocrinology Insulin resistance chemistry Erythrocyte sedimentation rate Internal medicine cardiovascular system medicine cardiovascular diseases Young adult business Lipid profile
Zdroj:	Journal of Digestive Diseases. 16:656-664
ISSN:	1751-2972
DOI:	10.1111/1751-2980.12297
Popis:	Objective To study the extent of early atherosclerosis in ulcerative colitis (UC) patients by measuring carotid intima–media thickness (CIMT) and the correlation between CIMT, serum homocysteine level and homeostasis model assessment-insulin resistance (HOMA-IR) in UC. Methods We studied 60 UC patients and 60 healthy controls. Individuals with risk factors for atherosclerosis were excluded from the study. Fasting blood glucose, lipid profile, HOMA-IR, erythrocyte sedimentation rate (ESR), serum vitamin B12 and homocysteine levels were measured in all participants. CIMT was measured using a B-mode duplex imaging study. Results UC patients had significantly higher CIMT than controls (P
Databáze:	OpenAIRE
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