Restoration of mean arterial pressure in endotoxic shock by meptazinol

Autor:	Martin H. Todd, Michael G. Wyllie, Peter M. Paciorek
Rok vydání:	1983
Předmět:	Pharmacology Mean arterial pressure genetic structures Chemistry Antagonist Meptazinol Biochemistry Norepinephrine (medication) Blood pressure medicine Opiate Receptor Antagonism medicine.drug
Zdroj:	Biochemical Pharmacology. 32:877-881
ISSN:	0006-2952
DOI:	10.1016/0006-2952(83)90591-9
Popis:	Meptazinol elevated mean arterial pressure in rats which had been treated with endotoxin. The drug also reduced the titer of circulating lysosomal enzymes. This effect was secondary to the restoration of mean arterial pressure (MAP). In vitro, meptazinol stabilised lysosomal membranes, increased noradrenaline release and interacted with the opiate receptor (naloxone-binding site) as an antagonist. The relevant contributions of these phenomena to the restoration of MAP are discussed.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::7d9b627ce20c8fe7d656f84a0428dd7b https://doi.org/10.1016/0006-2952(83)90591-9 Zobrazit plný text záznamu