Combined application of optical methods to increase the information content of optical coherent tomography in diagnostics of neoplastic processes
| Autor: | Natalia M. Shakhova, V. V. Sapozhnikova, Roman V. Kuranov, Valentin M. Gelikonov, E. V. Zagainova, S. A. Petrova |
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| Rok vydání: | 2002 |
| Předmět: |
Materials science
genetic structures business.industry Cross polarization Fluorescence spectrometry Statistical and Nonlinear Physics eye diseases Atomic and Molecular Physics and Optics Fluorescence spectroscopy Electronic Optical and Magnetic Materials Nuclear magnetic resonance Optics Uterine cervix Neoplastic Processes sense organs Tomography Electrical and Electronic Engineering Spectroscopy business |
| Zdroj: | Quantum Electronics. 32:993-998 |
| ISSN: | 1468-4799 1063-7818 |
| Popis: | A combined application of optical methods [optical coherent tomography (OCT), cross-polarisation optical coherent tomography, and fluorescence spectroscopy] is proposed for obtaining information on morphological and biochemical changes occurring in tissues in norm and pathology. It is shown that neoplastic and scar changes in esophagus can be distinguished using a combination of polarisation and standard OCT due to the difference between the depolarising properties of the tissues caused by the structural properties of collagenic fibres in stroma. It is shown that OCT combined with fluorescence spectroscopy with the use of 5-aminolevulinic acid is promising for determining the boundaries of carcinoma of the uterine cervix and vulva. It is found that the tumour boundary detected by optical methods coincides with the morphological boundary and extends beyond colposcopically determined boundary by about 2 mm. |
| Databáze: | OpenAIRE |
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