Microwave-assisted Cu-catalyzed C–C bond formation: one-pot synthesis of fully substituted 1,2,3-triazoles using nonsymmetrical iodoalkynes and their biological evaluation

Autor:	Sirassu Narsimha, Y. N. Reddy, Vasudeva Reddy Nagavelli, Kumara Swamy Battula
Rok vydání:	2018
Předmět:	In situ biology 010405 organic chemistry Aryl Organic Chemistry One-pot synthesis 010402 general chemistry biology.organism_classification 01 natural sciences Combinatorial chemistry In vitro 0104 chemical sciences Catalysis HeLa chemistry.chemical_compound chemistry Ionic liquid Microwave irradiation
Zdroj:	Chemistry of Heterocyclic Compounds. 54:1161-1167
ISSN:	1573-8353 0009-3122
DOI:	10.1007/s10593-019-02408-6
Popis:	A copper-catalyzed one-pot synthesis of fused benzothiazino[1,2,3]triazolo[4,5-c]quinolinone derivatives from 1-iodoalkynes with different aryl azides via an in situ generated 5-iodotriazole intermediate in [BMIM]PF6 under microwave irradiation is reported. The reaction provided the desired fused 1,2,3-triazoles in good to excellent yields. Anticancer activity of the synthesized compounds has been screened in vitro against different cancer cell lines (MCF-7, HeLa, A-549, and IMR-32). Some of the derivatives showed remarkable anticancer activity against two cancer cell lines – MCF-7 and A-549. The remaining compounds have shown good to moderate activity against tested cell lines.
Databáze:	OpenAIRE
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