Effect of prostaglandin E1 in collagen disease patients with inflammatory skin ulcer
| Autor: | Keiko Kumeno, Katufumi Shiozawa, Akemi Ohnishi, Masakuni Sugimoto, Yuichi Shiokawa, Naoki Uehara, Osamu Taniguchi, Toshio Tohijma |
|---|---|
| Rok vydání: | 1981 |
| Předmět: |
medicine.medical_specialty
Pathology Collagen disease Thrombocytosis Red Cell business.industry Skin ulcer medicine.disease Gastroenterology chemistry.chemical_compound medicine.anatomical_structure chemistry Internal medicine medicine lipids (amino acids peptides and proteins) Platelet medicine.symptom business Vein Prostaglandin E1 circulatory and respiratory physiology Whole blood |
| Zdroj: | Ensho. 1:255-260 |
| ISSN: | 1884-4006 0389-4290 |
| DOI: | 10.2492/jsir1981.1.2_255 |
| Popis: | Clinical, physiological and biochemical studies of PGE1 were done, in a series of collagen diseas patients with skin ulcer, foot varix patient with skin ulcer as non-inflammatory skin ulcer control, and 2 diabetics without skin ulcer as no skin ulcer control. Intra-venous infusions of prostaglandin E1 (PGE1) was given continuously in the dose of 1 ng/kg/min for 72 hours. Blood samples were collected from cubital vein, before, during, right after and at 7 days after PGE1 therapy. Platelet aggregations were studied by light transmittance (PRP: modified by Born's method, whole blood: modified by Tohjima's method) . Platelet iPG E (immunoreactive PG E like material) levels were assayed by radio-immunoassay. Essintial fatty acids compositions of plasma, pltelet and red cell were analyzed by gas chromatography.Results were as follows:(1) In all of cases, complete healing of skin ulcers was observed.(2) In most cases, skin temperature increased during PGE1 treatment.(3) Platelet aggregation was increased during PGE1 treatment than before one, and was higher in PRP than in whole blood, during PGE1 treatment.(4) The platelet basal iPGE levels were significantly decreased by PGE1 (p |
| Databáze: | OpenAIRE |
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