| Autor: |
Chang-Li Zheng, Rui-Xue Cheng, Hui Zheng, Zhong-Yuan Jin |
| Rok vydání: |
2003 |
| Předmět: |
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| Zdroj: |
World Chinese Journal of Digestology. 11:1677-1681 |
| ISSN: |
2219-2859 |
| DOI: |
10.11569/wcjd.v11.i11.1677 |
| Popis: |
AIM: To investigate the relationship between expressions of PTTG and c-myc genes and oncogenesis in human hepatocellular carcinomas(HCC). METHODS: In situ hybridization (DNA-RNA) and immunohistochemistry (SP method) methods were used to detect the expressions of PTTG and c-myc genes in 61 cases of human hepatocellular carcinomas . RESULTS: The distributions of positive cells of PTTG mRNA and PTTG protein in HCC were diffuse, aggregate or scattered. The positive stainings of PTTG mRNA and PTTG protein were plasma and submembrane types. The positive rates of PTTG mRNA and PTTG protein were 72.1 % (44/61) and 78.7 % (48/61) in HCC, and 93.4 % (57/61) and 91.8 % (56/61) in pericarcinomatous liver tissues. The expressions of PTTG mRNA and PTTG protein in HCC were significantly lower than those in paracancerous tissues (P |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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