THE ACTION OF DIETHYLSTILBESTROL IN GYNECOLOGICAL DYSFUNCTIONS

Autor: Raphael Kurzrok, William H. Perloff, Leo Wilson
Rok vydání: 1940
Předmět:
Zdroj: Endocrinology. 26:581-586
ISSN: 1945-7170
0013-7227
DOI: 10.1210/endo-26-4-581
Popis: DODDS ET AL. (1,2) described the estrogenic activity of certain derivatives of diphenylethane, and in particular it was shown that the introduction of an ethylene linkage between the α and β carbon atoms greatly increased the potency of the compounds. A number of stilbene derivatives were found to possess marked estrogenic activity. The most potent substance is 4, 4'dihydroxy α, β'diethylstilbene. It has the following activity as determined by the production of a vaginal estrous response. It will be noted from this that the new compound is about three times as active as estrone (I.U.=.0001 mg.). In view of the fact that 4, 4'dihydroxystilbene is the mother substance of a series of estrogenic agents, Dodds suggested that it be called “stilboestrol.”In the following clinical experiments we used a derivative, diethyl' stilbestrol. The structural resemblance of this compound to estrone can be seen in the following formulae.
Databáze: OpenAIRE