A NIR fluorescent probe for the in vitro and in vivo selective detection of hydrogen peroxide
| Autor: | Jin Yibo, Yang Yan, Ge Chunpo, Ren Feng, Tan Pengfei, Yang Yun, Shang Yuyang, Shi Hu |
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| Rok vydání: | 2022 |
| Předmět: |
inorganic chemicals
Detection limit Metals and Alloys Condensed Matter Physics Fluorescence In vitro Surfaces Coatings and Films Electronic Optical and Magnetic Materials chemistry.chemical_compound Fluorescence intensity symbols.namesake chemistry In vivo Stokes shift Materials Chemistry symbols Biophysics Electrical and Electronic Engineering Hydrogen peroxide Selectivity Instrumentation |
| Zdroj: | Sensors and Actuators B: Chemical. 350:130831 |
| ISSN: | 0925-4005 |
| DOI: | 10.1016/j.snb.2021.130831 |
| Popis: | In this study, we report the construction of a turn-on fluorescent probe, TMN-H2O2 with near-infrared emission for H2O2 detection in living systems. A series of experiments demonstrated that TMN-H2O2 exhibits a high selectivity for H2O2. After reaction with H2O2, TMN-H2O2 exhibited a 14.3-fold increase in fluorescence intensity at 660 nm and a 180 nm large Stokes shift. Moreover, TMN-H2O2 exhibited excellent sensitivity (limit of detection: 76 nM) and a fast response time (~40 min). The successful in vitro and in vivo application of TMN-H2O2 therefore suggested that this probe is a reliable chemical tool for monitoring both endogenous and exogenous H2O2. |
| Databáze: | OpenAIRE |
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