A Highly Efficient Base-Metal Catalyst: Chemoselective Reduction of Imines to Amines Using An Abnormal-NHC–Fe(0) Complex

Autor:	Swadhin K. Mandal, Debashis Adhikari, Mrinal Bhunia, Gonela Vijaykumar, Pradip Kumar Hota
Rok vydání:	2016
Předmět:	010405 organic chemistry Hydrosilylation Organic Chemistry Imine 010402 general chemistry 01 natural sciences 0104 chemical sciences Catalysis Inorganic Chemistry chemistry.chemical_compound chemistry Catalytic cycle Organic chemistry Physical and Theoretical Chemistry Chemoselectivity Base metal
Zdroj:	Organometallics. 35:2930-2937
ISSN:	1520-6041 0276-7333
DOI:	10.1021/acs.organomet.6b00478
Popis:	A base-metal, Fe(0)-catalyzed hydrosilylation of imines to obtain amines is reported here which outperforms its noble-metal congeners with the highest TON of 17000. The catalyst, (aNHC)Fe(CO)4, works under very mild conditions, with extremely low catalyst loading (down to 0.005 mol %), and exhibits excellent chemoselectivity. The facile nature of the imine reduction under mild conditions has been further demonstrated by reducing imines towards expensive commercial amines and biologically important N-alkylated sugars, which are difficult to achieve otherwise. A mechanistic pathway and the source of chemoselectivity for imine hydrosilylation have been proposed on the basis of the well-defined catalyst and isolable intermediates along the catalytic cycle.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::7d77fe276cd64ffeb6541259c8d48404 https://doi.org/10.1021/acs.organomet.6b00478 Zobrazit plný text záznamu