Magnetic resonance imaging abnormalities associated with vigabatrin in patients with epilepsy

Autor: M. Frost, Roy D. Elterman, Martina Bebin, Lionel Carmant, Juliann M. Paolicchi, Stephen D. Collins, Catherine Chiron, Mary L. Zupanc, Elizabeth A. Thiele, James W. Wheless, W. Donald Shields, Joan A. Conry
Rok vydání: 2009
Předmět:
Zdroj: Epilepsia. 50:195-205
ISSN: 1528-1167
0013-9580
DOI: 10.1111/j.1528-1167.2008.01896.x
Popis: Summary Purpose: Vigabatrin used to treat infantile spasms (IS) has been associated with transient magnetic resonance imaging (MRI) abnormalities. We carried out a retrospective review to better characterize the frequency of those abnormalities in IS and in children and adults treated with vigabatrin for refractory complex partial seizures (CPS). Methods: Medical records and 332 cranial MRIs from 205 infants (aged ≤24 months) with IS treated at 10 sites in the United States and Canada were collected. Similarly, 2,074 images from 668 children (aged 2–16 years) and adults (aged >16 years) with CPS were re-reviewed. Prespecified MRI abnormalities were defined as any hyperintensity on T2-weighted or fluid-attenuated inversion-recovery (FLAIR) sequences with or without diffusion restriction not readily explained by a radiographically well-characterized pathology. MRIs were read by two neuroradiologists blinded to treatment group. The incidence and prevalence of MRI abnormalities associated with vigabatrin were estimated. Results: Among infants with IS, the prevalence of prespecified MRI abnormalities was significantly higher among vigabatrin-treated versus vigabatrin-naive subjects (22% vs. 4%; p
Databáze: OpenAIRE
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