Inflammatory Mediators in Intra-abdominal Sepsis
| Autor: | Andrew W. Kirkpatrick, Jimmy Xiao, Craig N. Jenne, Derek J. Roberts |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
medicine.medical_specialty
business.industry Incidence (epidemiology) 030208 emergency & critical care medicine Inflammation Systemic inflammation medicine.disease Proinflammatory cytokine Sepsis 03 medical and health sciences 0302 clinical medicine medicine.anatomical_structure 030220 oncology & carcinogenesis Intensive care Case fatality rate medicine Abdomen medicine.symptom Intensive care medicine business |
| Zdroj: | Hot Topics in Acute Care Surgery and Trauma ISBN: 9783319597034 |
| Popis: | Although the case fatality rate of sepsis is improving, the absolute mortality is growing due to increasing worldwide incidence (Suarez De La Rica et al., Ann Transl Med 4:325, 2016). Further, the annual cost of treating sepsis in the United States is estimated to be $17 billion (Sepsis Fact Sheet, http://www.nigms.nih.gov/Education/Pages/factsheet_sepsis.aspx, 2014). Abdominal sepsis is a particularly challenging type, as interventions within the abdomen are frequently required for source control, yet the most severe manifestations are systemic. While supportive intensive care therapies and surgical correction of the inciting causes improve every year, this does not directly address the storms of biomediators that cause widespread inflammation and injury ultimately causing frequent death. To date, hundreds of pharmaceutical and biological agents have been tested without finding effective pharmacologic therapy targeting the action of biomediators. Therefore, a new paradigm is necessary, such as finding a way to block access of inflammatory cytokines to the bloodstream, before they can cause systemic inflammation. |
| Databáze: | OpenAIRE |
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