Effect of a Moderate Blood Exchange with Fluosol-Da 20% on the Disposition of Digoxin in the Dog

Autor: John F. Hoke, William R. Ravis
Rok vydání: 1987
Předmět:
Zdroj: MRS Proceedings. 110
ISSN: 1946-4274
0272-9172
DOI: 10.1557/proc-110-141
Popis: The effect of a perfluorochemical blood substitute (Fluosol-DA 20%) on the disposition kinetics of digoxin in the dog was studied. An intravenous dose of digoxin was administered at either 0.25 or 24 hours following a 30% blood exchange with the dog's own blood (SHAM group) or Fluosol-DA (treatment group). A significant change in the initial volume of distribution and mean residence time in the serum was noted when digoxin was administered 0.25 hours after the Fluosol-DA blood exchange. This volume of distribution change was not observed when digoxin was administered 24 hours after the Fluosol-DA blood exchange. No change in the t1/2, total body clearance, or volume of distribution at steady-state was observed in any of the treatments. No change in the partitioning of digoxin in the blood was noted following Fluosol-DA administration.
Databáze: OpenAIRE
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