Assessment of Specific and Non-specific Autoantibodies among Newly Diagnosed Type 1 Diabetes Mellitus Sudanese Patients
| Autor: | Hind Amin Ishaq, Mariam Abbas Ibrahim, Amar Mohammed Ismail, Nuha Eljaili Abubaker, Elyasa M Elfaki |
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| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | Biomedical and Pharmacology Journal. 15:1477-1482 |
| ISSN: | 2456-2610 0974-6242 |
| Popis: | Background: Pathogenesis of type 1 diabetes mellitus is associated with the presence of specific autoantibodies and viral infection. Herein we aim to assess specific and nonspecific autoantibodies in newly diagnosed type 1 diabetes mellitus patients. Materials and Methods: In this case-control study 200 subjects were enrolled, classified into 100 newly diagnosed type 1 diabetes mellitus patients ages ranged from 1 to 16 years old, and 100 apparently health control age matched group. Serum anti-glutamic acid decarboxylase/tyrosine Phosphatase 2 (anti-GAD/IA2), anti-tissue transglutaminase (anti-tTG) and antinuclear antibodies were measured. Results: Of 100, 62(62%) were males, and 38(38%) were females. Anti-GAD/IA2, anti-tTG, and antinuclear antibodies were found to be significantly higher in the case than in the control group. Anti-GAD/IA2 and anti-tTG were associated with higher risk of type 1 diabetes mellitus (OR= 5.44, P= 0.000) and (OR=5.82, P= 0.009) respectively. Conclusion: Anti-GAD/IA2, anti-tTG and antinuclear antibodies are higher in type 1 diabetes mellitus patients. Moreover, anti-GAD/IA2 and anti-tTG are associated with a high risk of type 1 diabetes mellitus. |
| Databáze: | OpenAIRE |
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