PTEN loss in biopsy tissue predicts poor clinical outcomes in prostate cancer

Autor: Steven Stone, Eliso Tikishvili, Jimmy Park, Julia Reid, Adib Younus, Zaina Sangale, Jerry S. Lanchbury, Emma H. Allott, Stephen J. Freedland, Leah R. Gerber, William Welbourn, Prabhakar Mithal
Rok vydání: 2014
Předmět:
Zdroj: International Journal of Urology. 21:1209-1214
ISSN: 0919-8172
DOI: 10.1111/iju.12571
Popis: Objectives To determine whether PTEN status in prostate biopsy represents a predictor of intermediate and long-term oncological outcomes after radical prostatectomy, and whether PTEN status predicts response to androgen deprivation therapy. Methods In a retrospective analysis of 77 men treated by radical prostatectomy who underwent diagnostic biopsy between 1992–2006, biopsy samples were stained for PTEN expression by the PREZEON assay with >10% staining reported as positive. Cox proportional hazards and log–rank models were used to assess the correlation between PTEN loss and clinical outcomes. Results During a median follow-up period after radical prostatectomy of 8.8 years, 39 men (51%) developed biochemical recurrence, four (5%) had castration-resistant prostate cancer, two (3%) had metastasis and two (3%) died from prostate cancer. PTEN loss was not significantly associated with biochemical recurrence (hazard ratio 2.1, 95% confidence interval 0.9–5.1, P = 0.10), but significantly predicted increased risk of castration-resistant prostate cancer, metastasis and prostate cancer-specific mortality (all log–rank, P
Databáze: OpenAIRE
Externí odkaz:
Nepřihlášeným uživatelům se plný text nezobrazuje