Synthesis of tritium labelled 20-hydroxy-hepoxilin A3, the major hepoxilin metabolite in human neutrophils
| Autor: | D. M. Kochev, L. L. Vasiljeva, Cecil R. Pace-Asciak, K. K. Pivnitsky, P. M. Demin |
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| Rok vydání: | 1999 |
| Předmět: |
chemistry.chemical_classification
Stereochemistry Chemistry Sodium Metabolite Organic Chemistry chemistry.chemical_element Epoxide Biochemistry Chemical synthesis Aldehyde Analytical Chemistry chemistry.chemical_compound Hepoxilin Drug Discovery Radiology Nuclear Medicine and imaging Tritium Specific activity Spectroscopy |
| Zdroj: | Journal of Labelled Compounds and Radiopharmaceuticals. 42:773-779 |
| ISSN: | 1099-1344 0362-4803 |
| Popis: | Methyl (8S)-[20-3H]-8,20-dihydroxy-11,12-epoxy-5Z,9E,14Z-eicosatrienoate ((8S)-[20-3H]-20-hydroxy-HxA3 methyl ester), a radioactive analog of the HxA3 metabolite was prepared. The synthesis of the 20-hydroxy analog of HxA3 methyl ester was performed by the reduction of the corresponding 20-aldehydro-HxA3 with sodium [3H]-borohydride. The purified [20-3H]-20-hydroxy-HxA3 methyl ester had a specific activity of 2.5–2.7 Ci/mmol. Copyright © 1999 John Wiley & Sons, Ltd. |
| Databáze: | OpenAIRE |
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