Review of PIXE studies of metal involvement in Reye's Syndrome

Autor: B.J. Wilder, R.W. Hurd, Joel M. Andres, H.A. Van Rinsvelt
Rok vydání: 1986
Předmět:
Zdroj: Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms. 14:221-225
ISSN: 0168-583X
DOI: 10.1016/0168-583x(86)90046-7
Popis: Children with Reye's Syndrome were found to have low levels of serum selenium. Two drugs associated with Reye's Syndrome, aspirin and valproic acid, decreased serum and hepatic levels of selenium in animals. A chemical (4-pentenoic acid) previously used to produce an animal model of Reye's Syndrome, was also found to alter selenium status. Changes in selenium and other trace metals may contribute to the pathophysiology of Reye's Syndrome and other neurological diseases. All analyses for trace element concentrations were performed by particle-induced X-ray emission.
Databáze: OpenAIRE