Review of PIXE studies of metal involvement in Reye's Syndrome
Autor: | B.J. Wilder, R.W. Hurd, Joel M. Andres, H.A. Van Rinsvelt |
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Rok vydání: | 1986 |
Předmět: |
Nuclear and High Energy Physics
Valproic Acid medicine.medical_specialty Aspirin Chemistry food and beverages chemistry.chemical_element medicine.disease behavioral disciplines and activities Serum selenium Pathophysiology Animal model Endocrinology Biochemistry Internal medicine medicine Reye's syndrome Instrumentation Selenium medicine.drug |
Zdroj: | Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms. 14:221-225 |
ISSN: | 0168-583X |
DOI: | 10.1016/0168-583x(86)90046-7 |
Popis: | Children with Reye's Syndrome were found to have low levels of serum selenium. Two drugs associated with Reye's Syndrome, aspirin and valproic acid, decreased serum and hepatic levels of selenium in animals. A chemical (4-pentenoic acid) previously used to produce an animal model of Reye's Syndrome, was also found to alter selenium status. Changes in selenium and other trace metals may contribute to the pathophysiology of Reye's Syndrome and other neurological diseases. All analyses for trace element concentrations were performed by particle-induced X-ray emission. |
Databáze: | OpenAIRE |
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