Total synthesis and absolute configuration determination of Ktedonoketone, a benzenoid metabolite from Thermophilic bacterium
| Autor: | Rahul Choudhury, D. Srinivasa Reddy, Monica Dandawate, Gamidi Rama Krishna |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
chemistry.chemical_classification
Natural product 010405 organic chemistry Metabolite Organic Chemistry Absolute configuration Total synthesis 010402 general chemistry 01 natural sciences Biochemistry Combinatorial chemistry 0104 chemical sciences Amino acid chemistry.chemical_compound Wacker process chemistry Drug Discovery Aldol condensation Enantiomer |
| Zdroj: | Tetrahedron Letters. 61:152526 |
| ISSN: | 0040-4039 |
| Popis: | The successful total synthesis of both enantiomers of ktedonoketone allowed us to decipher an unambiguous assignment of absolute configuration of the natural product. The concise synthesis highlights Wacker oxidation and aldol condensation as key steps. In addition to this, the current synthetic route is suitable to access a library of compounds on the similar skeleton as one can use readily available amino acids and Grignard reagents as variants. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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