N-Aryl-2-nitrosoanilines as intermediates in the synthesis of substituted phenazines from nitroarenes

Autor:	Adam Trawczyński, Karolina Stachowska, Zbigniew Wróbel, Andrzej Kwast
Rok vydání:	2011
Předmět:	Potassium carbonate chemistry.chemical_compound Acetic acid chemistry Trimethylsilyl Aryl Organic Chemistry Drug Discovery Pyocyanine Organic chemistry Methanol Biochemistry Acetamide
Zdroj:	Tetrahedron Letters. 52:6484-6488
ISSN:	0040-4039
DOI:	10.1016/j.tetlet.2011.09.113
Popis:	N-Aryl-2-nitrosoanilines, available from the reaction of nitroarenes with anilide anions, undergo cyclization to furnish substituted phenazines. The reaction is promoted by potassium carbonate in methanol, N,O-bis(trimethylsilyl)acetamide (BSA) in aprotic solvents, and by acetic acid. The method is illustrated by the synthesis of 1-methoxyphenazine, a precursor of pyocyanine, starting from the appropriate nitroarene–aniline pairs.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::7d2a95b8c041e39674129d912795720f https://doi.org/10.1016/j.tetlet.2011.09.113 Zobrazit plný text záznamu Full Text from ScienceDirect