Chemopreventive effects of elm tree bark extract on Helicobacter pylori-associated mouse gastric carcinogenesis
| Autor: | Youngsoo Kim, Sang-Kyung Shin, Sang-Yoon Nam, Dae Joong Kim, So-Young Youm, Tae-Wang Kim, Byeongwoo Ahn, Jin Tae Hong |
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| Rok vydání: | 2012 |
| Předmět: |
medicine.medical_specialty
Pathology biology Intestinal metaplasia Chronic gastritis Inflammation General Medicine Helicobacter pylori medicine.disease biology.organism_classification medicine.disease_cause Gastroenterology In vitro Pathology and Forensic Medicine Atrophy Ulmus davidiana Internal medicine medicine medicine.symptom Carcinogenesis |
| Zdroj: | Basic and Applied Pathology. 5:31-38 |
| ISSN: | 1755-9294 |
| Popis: | Background and aim: Extracts of elm tree (Ulmus davidiana japonica) have long been used for the treatment of inflammatory diseases in traditional medicine. Several in vitro studies have indicated that some components of the elm tree have anti-inflammatory and/or anti-oxidative effects. We investigated the chemopreventive effects of bark extract of elm tree (BEE) on a chronic inflammation-associated mouse gastric cancer model. Methods: Gastric cancer was generated by the combination treatment of N-methyl-N-nitrosourea and Helicobacter pylori to C57BL/6 mice. Various concentrations of BEE (0, 125, 250, 500, and 1,000 ppm) was fed to the mice for 38 weeks. Results: The incidence of gastric tumors at 50 weeks were significantly lower in the highest dose BEE-fed mice (26.67%) than control mice (85.71%) (P |
| Databáze: | OpenAIRE |
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