What members of the public think about taking part in medical research during an influenza pandemic: an international cross-sectional survey across eight OECD countries
| Autor: | Christopher C Butler, Steve Webb, Jill Mollison, Angela Watkins, Micaela Gal, Alistair Nichol, John-Paul Byrne, Victoria Harris, R. Moore, Nick A Francis, Nina Gobat, Prasanth Sukumar, Kerenza Hood |
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| Rok vydání: | 2018 |
| Předmět: |
education.field_of_study
medicine.medical_specialty Therapeutic misconception Cross-sectional study media_common.quotation_subject Population Comparative effectiveness research General Medicine Odds ratio Medical research Literacy Family medicine Preparedness Political science medicine education media_common |
| Zdroj: | The Lancet. 392:S1 |
| ISSN: | 0140-6736 |
| Popis: | Background Patients and the public are primary beneficiaries and contributors to pandemic-relevant clinical research. We aimed to understand their views about participation in and enrolment to comparative effectiveness research in primary and critical care settings during an influenza pandemic. Methods As part of the Platform for European Preparedness Against (Re-)emerging Epidemics (PREPARE), we conducted an international cross-sectional survey involving nationally representative samples of people in Belgium, Poland, Spain, Ireland, the UK, Canada, Australia, and New Zealand. Data were collected online using a scenario-based instrument during the 2017 regional influenza season. Scenarios involved research comparing routinely available treatments (low-risk research) and research to evaluate a new anti-viral treatment (higher risk). Descriptive and regression analyses were conducted. Findings 6804 individuals responded to the survey, of whom 5572 (82%) supported pandemic-relevant research and 5089 (75%) thought that “special rules” should apply to make it happen. Between 62% (Belgium, 530 of 850) and 67% (Spain, 572 of 850) of respondents would participate in low-risk primary care research. 48% (New Zealand, 408 of 850) to 58% (Australia, 491 of 851) would participate in a higher-risk primary care scenario. Between 66% (Spain, 558 of 850) and 75% (Australia, 639 of 851) of respondents would participate in low-risk intensive care unit (ICU) research. 54% (Spain, 445 of 850) to 66% (Australia, 559 of 851) would take part in a higher-risk ICU scenario. Therapeutic misconception was predictive of willingness to participate in all research scenarios (primary care low risk odds ratio 8·56 [95% CI 6·61–11·07], p Interpretation The public support pandemic-relevant clinical research. Public education, engagement, and policy initiatives to build research literacy are required to include a broader section of the population. Funding European Commission's FP7 programme (grant agreement 602525) for PREPARE, St Vincents Anaesthetic Foundation, Cardiff University. |
| Databáze: | OpenAIRE |
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