| Autor: | Steven D. Buckingham, Laurence A. Brown, Andrew K. Jones, Philip C. Biggin, David B. Sattelle, Luanda Pym, Mark S.P. Sansom |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
0303 health sciences
Mutation General Neuroscience Protein subunit Biology medicine.disease_cause 3. Good health 03 medical and health sciences Cellular and Molecular Neuroscience Nicotinic acetylcholine receptor 0302 clinical medicine Nicotinic agonist medicine Homomeric Cholinergic Receptor Neuroscience 030217 neurology & neurosurgery 030304 developmental biology Acetylcholine receptor |
| Zdroj: | BMC Neuroscience. 6:2 |
| ISSN: | 1471-2202 |
| DOI: | 10.1186/1471-2202-6-2 |
| Popis: | Background Nicotinic acetylcholine receptors (nAChRs) are pentameric proteins that are important drug targets for a variety of diseases including Alzheimer's, schizophrenia and various forms of epilepsy. One of the most intensively studied nAChR subunits in recent years has been α7. This subunit can form functional homomeric pentamers (α7)5, which can make interpretation of physiological and structural data much simpler. The growing amount of structural, pharmacological and physiological data for these receptors indicates the need for a dedicated and accurate database to provide a means to access this information in a coherent manner. |
| Databáze: | OpenAIRE |
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