Ros-mediated activation of NF-κB and Foxo during muscle disuse
| Autor: | Sarah M. Senf, Brittany J. Gagnon, Stephen L. Dodd, Andrew Judge, Brian A. Hain |
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| Rok vydání: | 2009 |
| Předmět: |
Soleus muscle
medicine.medical_specialty Physiology Skeletal muscle Biology medicine.disease medicine.disease_cause Muscle atrophy Cellular and Molecular Neuroscience Enzyme activator Transactivation Atrophy Endocrinology medicine.anatomical_structure Catalase Physiology (medical) Internal medicine medicine biology.protein Neurology (clinical) medicine.symptom Oxidative stress |
| Zdroj: | Muscle & Nerve. 41:110-113 |
| ISSN: | 0148-639X |
| Popis: | We examined reactive oxygen species as upstream activators of nuclear factor kappaB; (NF-kappaB) and forkhead box O (Foxo) in skeletal muscle during disuse atrophy. Catalase, an enzyme that degrades H2O2, was overexpressed in soleus muscles via plasmid injection prior to 7 days of hindlimb immobilization. The increased catalase activity abolished immobilization-induced transactivation of both NF-kappaB and Foxo and attenuated the loss of muscle mass. Thus, H2O2 may be an important initiator of these signaling pathways that lead to muscle atrophy. |
| Databáze: | OpenAIRE |
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