Effective Reversal of Warfarin-lnduced Excessive Anticoagulation with Low Dose Mtamin K1

Autor:	H. G. M. Shetty, G Backhouse, D P Bentley, P. A. Routledge
Rok vydání:	1992
Předmět:	Vitamin medicine.drug_class business.industry Anticoagulant Low dose Warfarin Hematology Anticoagulant control chemistry.chemical_compound chemistry Anticoagulant therapy Anesthesia Oral anticoagulant International normalised ratio medicine business medicine.drug
Zdroj:	Thrombosis and Haemostasis. 67:013-015
ISSN:	2567-689X 0340-6245
DOI:	10.1055/s-0038-1648371
Popis:	SummaryReversal of the anticoagulant effect of warfarin in patients with no active haemorrhage can be achieved by administration of intravenous vitamin K1. Currently recommended doses of intravenous vitamin K1, for this purpose often result in subsequent difficulties in anticoagulation. We observed the response to low dose intravenous vitamin K1 in patients requiring reversal of anticoagulant therapy. Ten consecutive patients received L mg and 2l further patients received 0.5 mg of intravenous vitamin K1. In 50% of the patients who received 1 mg of vitamin K1 the INR (International Normalised Ratio) fell below 2 at 24 h whereas in patients who received 0.5 mg the INR fell below 5.5 in all subjects after 24 h and in none did it fall below 2.0. No patient had any thrombotic or haemorrhagic complications and no difficulty was encountered in re-establishing anticoagulant control after 24 h. We recommend 0.5 mg of vitamin K1 as an effective and convenient method of predictable and fine control of oral anticoagulant therapy.
Databáze:	OpenAIRE
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