Convenient Synthesis and Antibacterial Activity of Tricyclic Azine Derivatives

Autor:	Fakhreia Al Sagheer, Abdel-Zaher A. Elassar, Abdulhakeem Alsughayer
Rok vydání:	2013
Předmět:	Azine chemistry.chemical_classification chemistry.chemical_compound chemistry Ethyl acetoacetate Isothiocyanate Organic chemistry Moderate activity General Chemistry Methylene Dimethylformamide-dimethylacetal Antibacterial activity Tricyclic
Zdroj:	Journal of Chemical Research. 37:248-252
ISSN:	2047-6507 1747-5198
DOI:	10.3184/174751913x13640546938841
Popis:	1,4-Phenylenediamine reacted readily with 2 mol of ethyl acetoacetate to give diethyl ( 2Z,2′Z)-3,3′-[(1,4-phenylene)-bisimino]dibut-2-enoate, which reacted with dimethylformamide dimethylacetal, activated methylene nitriles, ylidenemalononitriles and phenyl and benzoyl isothiocyanate to give, respectively, a 4,7-phenanthroline-2,9-dicarb-oxylate-1,10-diol, and tricyclic bispyridine and bispyrimidine derivatives. Two compounds showed strong antibacterial activity against several microorganisms, while six others showed high to moderate activity.
Databáze:	OpenAIRE
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