Investigation of inclusion complex of HP-γ-cyclodextrin with ceftazidime
| Autor: | Wieslawa Misiuk |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Stereochemistry
chemistry.chemical_element 02 engineering and technology 010402 general chemistry 021001 nanoscience & nanotechnology Condensed Matter Physics 01 natural sciences Sulfur Atomic and Molecular Physics and Optics 0104 chemical sciences Electronic Optical and Magnetic Materials Absorbance Crystallography chemistry.chemical_compound Ultraviolet visible spectroscopy chemistry Materials Chemistry Molecule Physical and Theoretical Chemistry Solubility Fourier transform infrared spectroscopy 0210 nano-technology Thiazole Spectroscopy Stoichiometry |
| Zdroj: | Journal of Molecular Liquids. 224:387-392 |
| ISSN: | 0167-7322 |
| DOI: | 10.1016/j.molliq.2016.10.009 |
| Popis: | The inclusion complex of ceftazidime (CF) with hydroxypropyl-γ-cyclodextrin (HP-γ-CD) was prepared. The inclusion behavior and interactions of CF with HP-γ-CD was carried out in both the solution and the solid state by UV/vis, FT-IR, NMR and molecular docking techniques. All the obtained information demonstrated the formation of CF-CD inclusion complex. The CF-CD inclusion complex exhibited different spectroscopic features and properties from CF. The results suggested that CF-CD inclusion complex was established with 1:1 stoichiometry. It was found that a part of CF molecule, the thiazole ring with sulfur and nitrogen atoms with C O and C N bands of CF was included in the HP-γ-CD cavity. Also the solubility and stability of CF-HP-γ-CD was significantly improved and consequently the bioavailability of CF through CF-CD inclusion complex was effectively improved over free CF. Based on the enhancement of absorbance of CF in the presence of HP-γ-CD a sensitive spectroscopic method for the CF determination was developed. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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