815 An Insertion of Eight Amino Acids in HLA-DQA1 and Three Amino Acid Substitutions in HLA-DQA1 and HLA-DQB1 Confer Risk to Idiopathic Achalasia

Autor: Vinod Kumar, Stefan Niebisch, Hauke Lang, Jessica Becker, Giovanni Zaninotto, Jan Tack, Ralf Kiesslich, Cisca Wijmenga, Ana G. Vigo, Guy E. Boeckxstaens, Gosia Trynka, Michael Knapp, Burkhard H.A. von Rahden, Paul I.W. de Bakker, Harm-Jan Westra, Michaela Mueller, Alexander J. Eckardt, Mira M. Wouters, Markus M. Noethen, Henning G. Schulz, Daniel Drescher, Lude Franke, Henning R. Gockel, Paola Brun, Johannes Schumacher, Ines Gockel
Rok vydání: 2013
Předmět:
Zdroj: Gastroenterology. 144:S-142
ISSN: 0016-5085
DOI: 10.1016/s0016-5085(13)60510-7
Popis: G A A b st ra ct s secretion volume despite significant decrease in intragastric acidity. Gastric secretion accumulates on the top of the liquid meal forming a "floating" layer. We assume that this layer is the correlate for the so called "acid pocket", which has previously been assumed according to several pH pull-through studies− the term "pocket" therefore being an unfavourable description. This phenomenon may be an important factor in the pathogenesis of GERD and in the persistence of GERD symptoms under PPI.
Databáze: OpenAIRE