Effect of neurotropin on seizure activity in picrotoxin kindling

Autor:	Godlevskiĭ Ls, Mazarati Am, Shandra Aa, Vast'ianov Rs
Rok vydání:	1992
Předmět:	Kindling business.industry medicine.medical_treatment Endogeny General Medicine Pharmacology Cycloheximide General Biochemistry Genetics and Molecular Biology Seizure susceptibility chemistry.chemical_compound Anticonvulsant chemistry Medicine sense organs Seizure activity business Picrotoxin
Zdroj:	Bulletin of Experimental Biology and Medicine. 113:298-302
ISSN:	1573-8221 0007-4888
Popis:	It is shown that both intracerebral and intraperitoneal neurotropin administration resulted in a decrease of seizure susceptibility of preliminary picrotoxin--kindled rats. On the other hand, neurotropin did not change the course of kindling development. Under conditions of acute picrotoxin--induced seizures it was observed that preliminary cycloheximide (protein-synthesis blocker) administration abolished anticonvulsant properties of neurotropin. It is concluded that anticonvulsant effects of neurotropin are realized via modulation of endogenous peptides synthesis and, in particular, cerulein.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::7cfb477d7e68e72ba4791cb5ea918889 https://doi.org/10.1007/bf00783098 Zobrazit plný text záznamu Full text from SpringerLink