Phytochemical Screening, Phenolic Compounds Content, Antioxidant, Anti-inflammatory, and Antimicrobial Properties of Pachylobus balsamifera Guillaum from Gabon
| Autor: | Cédric Sima-Obiang, Guy-Roger Ndong-Atome, Rick-Leonid Ngoua-Meye-Misso, E. Nsi-Emvo, Louis-Clément Obame-Engonga, J. Privat Ondo |
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| Rok vydání: | 2018 |
| Předmět: |
Pharmacology
Salmonella Antioxidant ABTS biology 010405 organic chemistry Chemistry DPPH medicine.medical_treatment Salmonella typhi medicine.disease_cause biology.organism_classification Antimicrobial 01 natural sciences 0104 chemical sciences 010404 medicinal & biomolecular chemistry chemistry.chemical_compound Complementary and alternative medicine Phytochemical Salmonella enterica medicine Food science |
| Zdroj: | Phytothérapie. 16:S65-S73 |
| ISSN: | 1765-2847 1624-8597 |
| DOI: | 10.3166/phyto-2018-0059 |
| Popis: | The goal of this work is to evaluate the antioxidant anti-inflammatory properties, the phenolic compounds content, and antimicrobial potential of water–acetone, water–ethanol, and water extracts of Pachylobus balsamifera. The phenolic compounds content was evaluated to estimate their effect on the antioxidant, anti-inflammatory, and antimicrobial potential of the plant. Antioxidant activities were examined by DPPH (2,2-diphenyl-1- picrylhydrazyl) and ABTS (2,2′-azino-bis) assays. Antiinflammatory activity was determined by the proteins denaturation inhibition method. All plant extracts were evaluated against six reference strains, eleven clinical isolates, and two fungal strains. Phenols content was highest in the water–acetone and water–ethanol extracts. The water extract showed strong anti-inflammatory effect. The water–acetone extract presented a strong antioxidant property and the highest antimicrobial activities against Pseudomonas aeruginosa, Acinetobacter baumannii, Salmonella Sp., and Neisseria meningitidis. The tested microorganisms showed sensitivity to all extracts of the plant with the exception of Escherichia coli 105182 CIP, Listeria innocua LMG 135668 BHI, Salmonella enterica, Salmonella typhi, and Neisseria gonorrhea. Our results suggest that Pachylobus balsamifera extracts contain antioxidant, anti-inflammatory, and antimicrobial properties. |
| Databáze: | OpenAIRE |
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