Synthesis of pyrazoles with fluorinated side-chain by cyclization of fluoroalkylated triketides

Autor:	Marleen Winterberg, Christine Fischer, Peter Langer, Stefan Büttner, Alexander Villinger, Dirk Michalik, Ashot S. Saghyan, Willi Desens
Rok vydání:	2013
Předmět:	Acetic acid chemistry.chemical_compound Hydroxylamine chemistry Organic Chemistry Drug Discovery Side chain Regioselectivity Organic chemistry Organofluorine compounds Biochemistry Tautomer
Zdroj:	Tetrahedron. 69:3459-3464
ISSN:	0040-4020
DOI:	10.1016/j.tet.2013.02.059
Popis:	The cyclization of fluoroalkylated 3,5-dioxoesters with hydrazines, carried out in glacial acetic acid, afforded pyrazines with fluoroalkylated side-chain. The cyclization of 3,5-dioxoesters with hydroxylamine afforded hydroxylated fluoroalkylated dihydroisoxazoles. All reactions proceeded with good to very good regioselectivity.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::7cf2a0299b7a466c4529eb2fa86e55cf https://doi.org/10.1016/j.tet.2013.02.059 Zobrazit plný text záznamu Full Text from ScienceDirect