Surface roughness dependent osteoblast and fibroblast response on poly(l -lactide) films and electrospun membranes
| Autor: | Clarisse Ribeiro, A. C. Areias, F. Miguel Gama, Senentxu Lanceros-Méndez, Vitor Sencadas |
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| Rok vydání: | 2014 |
| Předmět: |
Materials science
Metals and Alloys Biomedical Engineering Osteoblast 02 engineering and technology Surface finish 010402 general chemistry 021001 nanoscience & nanotechnology 01 natural sciences 0104 chemical sciences Biomaterials Crystallinity medicine.anatomical_structure Poly-L-lactide Ceramics and Composites medicine Surface roughness Fiber Composite material 0210 nano-technology Fibroblast Microscale chemistry Biomedical engineering |
| Zdroj: | Journal of Biomedical Materials Research Part A. 103:2260-2268 |
| ISSN: | 1549-3296 |
| DOI: | 10.1002/jbm.a.35367 |
| Popis: | Poly(l-lactide) electrospun mats with random and aligned fiber orientation and films have been produced with degrees of crystallinity ranging from 0 up to nearly 50%. The overall surface roughness is practically constant irrespective of the sampling areas (1 × 1 µm to 20 × 20 µm) for degrees of crystallinity below 30%, increasing for higher degrees of crystallinity for the larger sampling areas. Further, due to fiber confinement, surface roughness variations are smaller in electrospun mats. Samples with 50% of crystallinity show the lowest osteoblast and the highest fibroblast proliferation. Therefore, it is verified that higher roughness promotes lower osteoblast but higher fibroblast proliferation. The overall results indicate the relevant role of the sub-microenvironment variations associated to the microscale roughness in determining the different cell responses. |
| Databáze: | OpenAIRE |
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