Microfluidic applications on pancreatic islets and β-cells study for human islet transplant
| Autor: | Farid Ghamsari, Xiaoyu Yu, Jose Oberholzer, Sharon Lu, Sarah E. Innis, Joshua E. Mendoza-Elias, Melur K. Ramasubramanian, Yi He, Pu Zhang, Yong Wang, Yuan Xing |
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| Rok vydání: | 2021 |
| Předmět: |
endocrine system
geography geography.geographical_feature_category endocrine system diseases business.industry Pancreatic islets Islet Key issues humanities Cell biology Clinical therapy surgical procedures operative medicine.anatomical_structure Medicine Type i diabetes Pancreatic islet transplantation business health care economics and organizations |
| Zdroj: | Microfluidic Devices for Biomedical Applications ISBN: 9780128199718 |
| Popis: | This chapter discusses various microfluidic technologies that have been developed to study and encapsulate human islets for transplant. The chapter first introduces key issues in the field of pancreatic islet transplantation as a clinical therapy for Type I diabetes. It then reviews microfluidic technologies that have been developed for the study of pancreatic islet and β-cell physiology, disease pathophysiology, and human islets microencapsulation for transplant. Furthermore, the chapter describes the design, fabrication, and application of our current microfluidic systems for multimodal islet perifusion, imaging, and encapsulation with detailed protocols that are available at the end of the chapter. |
| Databáze: | OpenAIRE |
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