Ionic Modulation of Calcium Dynamics in Simulated Human Heart Failure
| Autor: | Jose M Ferrero, Maria T. Mora, Beatriz Trenor |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty SERCA Chemistry Diastole chemistry.chemical_element 030204 cardiovascular system & hematology Calcium medicine.disease Ventricular action potential Contractility Coupling (electronics) 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Calcium dynamics Heart failure Internal medicine medicine Cardiology |
| Zdroj: | CinC |
| ISSN: | 2325-887X |
| DOI: | 10.22489/cinc.2017.248-074 |
| Popis: | Calcium mishandling observed in failing hearts is responsible for contractile dysfunction and arrhythmias. Thereby, calcium dynamics becomes an important target to explore for the restoration of the altered excitation-contraction coupling. In this study, we performed an in-silico sensitivity analysis to understand the mechanisms modulating calcium dynamics in failing human hearts. Using a modified version of the O'Hara et al. human ventricular action potential model, we simulated different failing conditions for every ionic parameter remodeled in heart failure. Calcium biomarkers from simulated endocardial cells, such as systolic and diastolic calcium concentration, were measured and analyzed. The results of this study highlight the importance of maintaining SERCA activity in its normal levels to improve contractility and point to other crucial parameters that also alter calcium handling, such as NCX. |
| Databáze: | OpenAIRE |
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