MATRIX METALLOPROTEINASES IN CHILDREN WITH A COMBINED BONE INJURY
| Autor: | Ivan. E. Smirnov, V. A. Mitish, L. M. Roshal, I. V. Ponina, Kucherenko Ag, O. V. Karaseva |
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| Rok vydání: | 2019 |
| Předmět: | |
| Zdroj: | Russian Pediatric Journal. 22:170-175 |
| ISSN: | 2413-2918 1560-9561 |
| Popis: | There were comprehensively examined 55 children, including 35 children with combined bone injury (average age of 12.6 ± 2.3 years), reference group consisted of 20 apparently healthy children (average age of 11.8 ± 2.7 years) without pathology of the motor system. on the 1-3rd and 30th day after the combined bone injury, changes in the content of matrix metalloproteinases (MMP) and cytokines - transforming growth factor-beta (TGF-β), monocytic chemotactic factor (MCP-1) and macrophage inflammatory protein (MIP-1β) were followed in the dynamics by serum immunoassay determination. It was established that after combined bone injury at the stage of post-traumatic formation of the regenerate by 30th days the serum concentrations of gelatinases (MMP-2, MMP-9) and collagenases (MMP-8) significantly increased, the levels of stromelysins (MMP-3) did not change, and the content of TIMP-1 decreased. Early detection of changes in the blood content of bone biomarkers during the recovery process after a combined trauma in children allows the timely implementing the correction of disturbances and the choice of the optimal individual treatment tactics for a particular patient, taking into account the features of his bone metabolism. |
| Databáze: | OpenAIRE |
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