Coagulation and fibrinolytic potential of blood plasma in patients with stage VD CKD, treated by program hemodialysis, as the markers of thrombotic risk
| Autor: | Y.A. Danylenko, B. G. Storozhuk, O. B. Storozhuk, T. V. Dovgalyuk, L. O. Storozhuk, I. B. Seleznyova |
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| Rok vydání: | 2018 |
| Předmět: | |
| Zdroj: | Reports of Vinnytsia National Medical University. 22:494-497 |
| ISSN: | 2522-9354 1817-7883 |
| DOI: | 10.31393/reports-vnmedical-2018-22(3)-20 |
| Popis: | Thrombotic complications, associated with hemostatic system disturbances in patients with stage VD chronic kidney disease (CKD), occur rather frequently. Hence, the search of early available biological markers in diagnosis of this complication is of great significance. Objective – to study coagulation potential of blood plasma in patients with stage VD CKD, treated by program hemodialysis, and to determine the markers of thrombotic risk. 88 patients (aged 26–65) with stage VD CKD, treated by program hemodialysis, were studied. Hemostatic potential of blood was determined by spectrophotometry; soluble fibrin level — by two-site enzyme-linked immune-sorbent quantitative assay; D-dimer — by enzyme immunoassay using monoclonal antibodies to D-dimer epitopes; protein C activity — by spectrophotometry with wavelength 405 nm; fibrinogen contents — by spectrophotometry with wavelength 280 nm. Statistical processing was performed by methods of variation statistics and correlation analysis. All patients were found to have significant increase of soluble fibrin level (4.03±0.15÷4.62±0.31 mg/ml) (р |
| Databáze: | OpenAIRE |
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