A simple selective protocol for continuous two-stage fluorescent sensing of both MeHg+ and anti-MeHg+ agents in living cells

Autor:	Zhu-Jun Yao, Lei Chen, Bao-Kun He, De-Sheng Mei
Rok vydání:	2012
Předmět:	chemistry.chemical_compound Chemistry Environmental chemistry Organic Chemistry Drug Discovery Biophysics Biochemistry Visualization model Fluorescence Methylmercury
Zdroj:	Tetrahedron Letters. 53:3463-3466
ISSN:	0040-4039
DOI:	10.1016/j.tetlet.2012.04.113
Popis:	Methylmercury (MeHg+) is one of the most toxic mercury species targeting human nervous systems, and deficiency of a convenient and precise appraisal model for anti-MeHg+ treatment greatly slows down the step of developing clinically useful anti-MeHg+ agents. A simple visualization model has been demonstrated in this work for selective sensing of both MeHg+ and anti-MeHg+ agents in two continuous stages of one experiment in living cells, using a newly developed fluorescent pyrrolcoumarin probe. The developed sensing protocol shows great potential in the future applications of screening and evaluation of anti-MeHg+ agents.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::7cd58ffc84a94dcddf240552cbebf04a https://doi.org/10.1016/j.tetlet.2012.04.113 Zobrazit plný text záznamu Full Text from ScienceDirect