Diels-Alder reactions in the presence of a minimal amount of water

Autor:	Veljko Dragojlovic, Nicole Windmon
Rok vydání:	2008
Předmět:	Reaction rate chemistry.chemical_compound Cyclopentadiene Solvent free chemistry Diels alder Environmental Chemistry Organic chemistry Maleic anhydride General Chemistry Environmentally friendly Adduct Suspension (chemistry)
Zdroj:	Green Chemistry Letters and Reviews. 1:155-163
ISSN:	1751-7192 1751-8253
DOI:	10.1080/17518250802482505
Popis:	Diels-Alder reactions of neat reactive dienes and dienophiles are frequently vigorous and have a limited preparative value. It is possible to control the temperature of multi-gram scale Diels-Alder reactions by adding a minimal amount of water to neat reactants. In addition, the presence of water resulted in an increased reaction rate and formation of a higher purity product. The use of minimal amounts of other solvents, with lower heat capacities, did not give good results. Furthermore, some dienophiles, e.g. maleic anhydride, reacted poorly in a dilute water suspension or solution, but worked well in the presence of a minimal amount of water. This is an environmentally friendly, practical and efficient approach to preparation of Diels-Alder adducts on a multi-gram scale.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::7cd4d2ad781edb27a779d7d0461f0e93 https://doi.org/10.1080/17518250802482505 Zobrazit plný text záznamu