Chromosomes and causation of human cancer and leukemia.VI. Blastic phase, cellular origin, and the Ph1 in CML

Autor:	Ediz Z. Ezdinli, Dieter K. Hossfeld, Avery A. Sandberg, Lois H. Crosswhite
Rok vydání:	1971
Předmět:	Cancer Research business.industry Incidence (epidemiology) Cell Blastic Phase medicine.disease Leukemia Cellular origin medicine.anatomical_structure Oncology hemic and lymphatic diseases Immunology Medicine High incidence Stem cell business Human cancer
Zdroj:	Cancer. 27:176-185
ISSN:	1097-0142 0008-543X
DOI:	10.1002/1097-0142(197101)27:1<176::aid-cncr2820270125>3.0.co;2-b
Popis:	The cytogenetic, histologic, and pertinent clinical data on 107 cases of CML from our laboratory and those from the literature on the incidence of Ph1-negative cells in marrows of patients with Ph1-positive CML have been collected and summarized. In addition, the distribution of multiple Ph1-chromosomes in 5 cases of CML, with and without the blastic phase, has been described and discussed. The findings served as a basis for caution in utilizing the high incidence of Ph1-positive cells in the marrows of the preponderant number of patients with CML as support for the unicellular stem cell origin of such cells. The occurrence of Ph1-negative cells in significant percentages in some patients with chronic myelocytic leukemia indicates that several other hypotheses, including a multi-stem cell origin of marrow cells, are compatible with the observations in CML.
Databáze:	OpenAIRE
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