Continuous Production of Spherical Multicrystals by Extractive Crystallization in a Droplet Based Fluidic Device
| Autor: | Martin Kalný, Aleš Zadražil, František Štěpánek, Anna Pittermannová |
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| Rok vydání: | 2017 |
| Předmět: |
Supersaturation
Aqueous solution Materials science 010405 organic chemistry Dispersity Aqueous two-phase system General Chemistry 010402 general chemistry Condensed Matter Physics 01 natural sciences 0104 chemical sciences law.invention Crystal Crystallography Chemical engineering law Phase (matter) General Materials Science Crystallization Dissolution |
| Zdroj: | Crystal Growth & Design. 17:3700-3706 |
| ISSN: | 1528-7505 1528-7483 |
| Popis: | A novel continuous fluidic method based on extractive crystallization for producing monodisperse spherical crystal aggregates with potential use in pharmaceutical engineering is presented. A model system of aqueous solution containing KCl as the precursor dispersed phase and 1-hexanol as the continuous extraction phase was investigated experimentally. Monodisperse droplets of the aqueous phase were generated by a fluidic T-junction in the stable dripping regime. Supersaturation was achieved by extraction of the aqueous phase into the organic phase. The effect of extraction rate on the size, morphology, and internal pore structure of the resulting spherical crystal aggregates was systematically investigated. It was shown that nearly monodisperse particles with a tunable size can be produced by adjusting the initial solute concentration. The dissolution rates of the resulting spherical aggregates were measured and compared with single cubic crystals of identical mass. It was shown that a four- to five-fold ... |
| Databáze: | OpenAIRE |
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